Enhancing insulin oral absorption by using mucoadhesive nanoparticles loaded with LMWP-linked insulin conjugates.
作者： Jianyong Sheng , Huining He , Limei Han , Jing Qin , Sunhui Chen
DOI: 10.1016/J.JCONREL.2016.05.015
关键词:
摘要: Although significant progress has been achieved, effective oral delivery of protein drugs such as insulin by nanoparticle-based carrier systems still faces certain formidable …
sci-hub.se 参考文章(46)
Isabel Behrens, Ana Isabel Vila Pena, Maria José Alonso, Thomas Kissel, Comparative Uptake Studies of Bioadhesive and Non-Bioadhesive Nanoparticles in Human Intestinal Cell Lines and Rats: The Effect of Mucus on Particle Adsorption and Transport Pharmaceutical Research. ,vol. 19, pp. 1185- 1193 ,(2002) , 10.1023/A:1019854327540
Isabel Behrens, Patric Stenberg, Per Artursson, Thomas Kissel, Transport of lipophilic drug molecules in a new mucus-secreting cell culture model based on HT29-MTX cells. Pharmaceutical Research. ,vol. 18, pp. 1138- 1145 ,(2001) , 10.1023/A:1010974909998
Agneta Wikman Larhed, Per Artursson, Erik Björk, The Influence of Intestinal Mucus Components on the Diffusion of Drugs Pharmaceutical Research. ,vol. 15, pp. 66- 71 ,(1998) , 10.1023/A:1011948703571
Yan Zhang, Zhijie Yang, Xi Hu, Ling Zhang, Feng Li, Meimei Li, Xing Tang, Wei Xiao, Development and evaluation of mucoadhesive nanoparticles based on thiolated Eudragit for oral delivery of protein drugs Journal of Nanoparticle Research. ,vol. 17, pp. 98- ,(2015) , 10.1007/S11051-015-2909-5
Nathalie Reix, Audrey Parat, Elodie Seyfritz, Remmelt Van Der Werf, Virginia Epure, Nicolas Ebel, Louis Danicher, Eric Marchioni, Nathalie Jeandidier, Michel Pinget, Yves Frère, Séverine Sigrist, In vitro uptake evaluation in Caco-2 cells and in vivo results in diabetic rats of insulin-loaded PLGA nanoparticles International Journal of Pharmaceutics. ,vol. 437, pp. 213- 220 ,(2012) , 10.1016/J.IJPHARM.2012.08.024
Kiran Sonaje, Kun-Ju Lin, Jiun-Jie Wang, Fwu-Long Mi, Chiung-Tong Chen, Jyuhn-Huarng Juang, Hsing-Wen Sung, Self‐Assembled pH‐Sensitive Nanoparticles: A Platform for Oral Delivery of Protein Drugs Advanced Functional Materials. ,vol. 20, pp. 3695- 3700 ,(2010) , 10.1002/ADFM.201001014
Li-Chien Chang, Shirley Wrobleski, Thomas W. Wakefield, Lai Ming Lee, Victor C. Yang, Low molecular weight protamine as nontoxic heparin/low molecular weight heparin antidote (III): Preliminary in vivo evaluation of efficacy and toxicity using a canine model Aaps Pharmsci. ,vol. 3, pp. 24- 31 ,(2001) , 10.1208/PS030319
Piyasi Mukhopadhyay, Kishor Sarkar, Mousumi Chakraborty, Sourav Bhattacharya, Roshnara Mishra, P.P. Kundu, Oral insulin delivery by self-assembled chitosan nanoparticles: In vitro and in vivo studies in diabetic animal model Materials Science and Engineering: C. ,vol. 33, pp. 376- 382 ,(2013) , 10.1016/J.MSEC.2012.09.001
Jun F. Liang, Victor C. Yang, Insulin-cell penetrating peptide hybrids with improved intestinal absorption efficiency. Biochemical and Biophysical Research Communications. ,vol. 335, pp. 734- 738 ,(2005) , 10.1016/J.BBRC.2005.07.142
Catherine Pontier, Jean Pachot, Roger Botham, Bernard Lenfant, Philippe Arnaud, HT29‐MTX and Caco‐2/TC7 Monolayers as Predictive Models for Human Intestinal Absorption: Role of the Mucus Layer Journal of Pharmaceutical Sciences. ,vol. 90, pp. 1608- 1619 ,(2001) , 10.1002/JPS.1111