Tumour microvessel density as predictor of chemotherapy response in breast cancer patients
作者： O Tynninen , J Sjöström , K von Boguslawski , N O Bengtsson , R Heikkilä
关键词:
摘要: The aim of this study was to evaluate the predictive value intratumoural microvessel density in breast cancer. We studied immunohistochemically primary tumours 104 patients with metastasised cancer who took part a randomised multicentre trial comparing docetaxel sequential methotrexate and 5-fluorouracil. Vessels were highlighted factor VIII staining counted microscopically. Microvessel compared clinical response chemotherapy patient survival. tumour not significantly associated patient's chemotherapy, time progression or overall survival whole population 5-fluorouracil groups. However, disease-free longer low (P=0.01). These findings suggest that cannot be used as marker for advanced
core.ac.uk
nature.com
researchgate.net 
sci-hub.se 参考文章(31)
Paolo Verderio, Pierantonio Bevilacqua, Stephen B. Fox, Patrizia Boracchi, Ettore Marubini, Emanuela Bonoldi, Stefania Dante, Giampietro Gasparini, Adrian L. Harris, Determination of angiogenesis adds information to estrogen receptor status in predicting the efficacy of adjuvant tamoxifen in node-positive breast cancer patients. Clinical Cancer Research. ,vol. 2, pp. 1191- 1198 ,(1996)
Werner Vach, Dorthe A. Grabau, Martin Bak, Flemming B. Sørensen, Carsten Rose, Steinbjørn Hansen, The Prognostic Value of Angiogenesis by Chalkley Counting in a Confirmatory Study Design on 836 Breast Cancer Patients Clinical Cancer Research. ,vol. 6, pp. 139- 146 ,(2000)
R. K. Vartanian, N. Weidner, Correlation of intratumoral endothelial cell proliferation with microvessel density (tumor angiogenesis) and tumor cell proliferation in breast carcinoma. American Journal of Pathology. ,vol. 144, pp. 1188- 1194 ,(1994)
P. C. Willsher, S. E. Pinder, S. Y. Chan, Robert Ian Nicholson, Julia Margaret Wendy Gee, J. F. R. Robertson, R. W. Blamey, I. O. Ellis, C-erbB2 expression predicts response to preoperative chemotherapy for locally advanced breast cancer. Anticancer Research. ,vol. 18, pp. 3695- 3698 ,(1998)
Trond Paulsen, Turid Aas, Anne-Lise Borresen, Jan Erik Varhaug, Per E. Lønning, Lars A. Akslen, Angiogenesis does not predict clinical response to doxorubicin monotherapy in patients with locally advanced breast cancer International Journal of Cancer. ,vol. 74, pp. 138- 140 ,(1997) , 10.1002/(SICI)1097-0215(19970220)74:1<138::AID-IJC23>3.0.CO;2-A
Jocelyne D. Jacquemier, Frederique M. Penault-Llorca, Francois Bertucci, Zhen Z. Sun, Gilles F. Houvenaeghel, Jeanine A. Geneix, Brigitte D. Puig, Valerie Jeanne H. Bardou, Jacques A. Hassoun, Daniel Birnbaum, Patrice J. Viens, Angiogenesis as a prognostic marker in breast carcinoma with conventional adjuvant chemotherapy: a multiparametric and immunohistochemical analysis. The Journal of Pathology. ,vol. 184, pp. 130- 135 ,(1998) , 10.1002/(SICI)1096-9896(199802)184:2<130::AID-PATH19>3.0.CO;2-W
A.M. Schor, M.E.H.M. Van Hoef, S.S. Dhesi, A. Howell, W.F. Knox, Assessment of tumour vascularity as a prognostic factor in lymph node negative invasive breast cancer European Journal of Cancer. ,vol. 29, pp. 1141- 1145 ,(1993) , 10.1016/S0959-8049(05)80304-1
Masakazu Toi, Kazuo Inada, Hideo Suzuki, Takeshi Tominaga, Tumor angiogenesis in breast cancer: Its importance as a prognostic indicator and the association with vascular endothelial growth factor expression Breast Cancer Research and Treatment. ,vol. 36, pp. 193- 204 ,(1995) , 10.1007/BF00666040
Laura Medri, Oriana Nanni, Annalisa Volpi, Emanuela Scarpi, Alessandra Dubini, Angela Riccobon, Aldo Becciolini, Simonetta Bianchi, Dino Amadori, Tumor microvessel density and prognosis in node-negative breast cancer International Journal of Cancer. ,vol. 89, pp. 74- 80 ,(2000) , 10.1002/(SICI)1097-0215(20000120)89:1<74::AID-IJC12>3.0.CO;2-L
Anne Vincent-Salomon, Matthieu Carton, Brigitte Zafrani, Paul Fr�neaux, Andr� Nicolas, Blandine Massemin, Alain Fourquet, Krishna Clough, Pierre Pouillart, Xavier Sastre-Garau, Long term outcome of small size invasive breast carcinomas independent from angiogenesis in a series of 685 cases Cancer. ,vol. 92, pp. 249- 256 ,(2001) , 10.1002/1097-0142(20010715)92:2<249::AID-CNCR1316>3.0.CO;2-P