Gray-matter relationships to diagnostic and transdiagnostic features of drug and behavioral addictions.

摘要: Alterations in neural structure have been reported both cocaine-use disorder and gambling disorder, separately, suggesting similarities across addiction diagnoses. Individual variation has also associated with impulsivity, a dimensional construct implicated addictions. This study combines categorical (diagnosis-based) (transdiagnostic) approaches to identify structural alterations linked subtypes trait respectively, individuals (n = 35), (n = 37) healthy comparison (n = 37). High-resolution T1-weighted data were analyzed using modulated voxel-based morphometry (VBM). Statistical analyses conducted whole-brain general-linear models, corrected for family-wise error (pFWE < .05). Categorical indicated main effect of diagnostic group on prefrontal (dorsal anterior cingulate ventromedial cortex) gray matter volumes (GMVs), involving decreased GMVs among participants only. Dimensional negative association between impulsivity cortical (insula) subcortical (amygdala hippocampus) all participants. Conjunction analysis little anatomical overlap regions identified as differentiating groups covarying impulsivity. These provide first evidence differences an illicit substance-use disorder. They further indicate dissociable effects groupings behavioral drug Study findings highlight the importance considering (e.g. Research Domain Criteria; RDoC) within context addictions research.