Brain Activity During Cocaine Craving and Gambling Urges: An fMRI Study.

作者: Hedy Kober , Cheryl M Lacadie , Bruce E Wexler , Robert T Malison , Rajita Sinha

DOI: 10.1038/NPP.2015.193

关键词: CravingInsulaAnterior cingulate cortexVentromedial prefrontal cortexBrain mappingAddictionPsychiatryFunctional magnetic resonance imagingPsychologyCocaine dependence

摘要: Although craving states are important to both cocaine dependence (CD) and pathological gambling (PG), few studies have directly investigated neurobiological similarities differences in between these disorders. We used functional magnetic resonance imaging (fMRI) assess brain activity 103 participants (30 CD, 28 PG, 45 controls) while they watched videos depicting cocaine, gambling, sad scenarios investigate the neural correlates of craving. observed a three-way urge type × video diagnostic group interaction self-reported craving, with CD reporting strong cravings videos, PG urges videos. Neuroimaging data revealed anterior cingulate cortex/ventromedial prefrontal cortex (mPFC), activating predominantly participants, more dorsal mPFC region that was most strongly activated for control participants. Gender diagnosis interactions identified posterior insula/caudate which female but not male showed increased responses Findings illustrate drug PG. Future should diagnostic- gender-specific therapies targeting systems implicated craving/urge addictions.

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