Reduced ovarian function in long-term survivors of radiation- and chemotherapy-treated childhood cancer.
作者： Elisabeth C. Larsen , Jørn Müller , Kjeld Schmiegelow , Catherine Rechnitzer , Anders Nyboe Andersen
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摘要: Seventy percent of children with cancer survive. Radiation and chemotherapy may, however, impair ovarian function. The aim this population-based study was to achieve a comprehensive knowledge the degree damage. Ovarian function evaluated in 100 childhood survivors 21 controls similar age. Menstrual cycle pattern recorded, strictly timed sonography hormonal assessment were performed. median age 5.4 yr (range, 0.1–15.3) at time diagnosis 25.7 (18.5–44.4) entry. Seventeen premature failure had follicle-depleted or nondetectable ovaries, elevated FSH LH, immeasurable inhibin B. Thirteen used oral contraception. Survivors spontaneous menstrual cycles (n = 70) smaller volume per ovary than (median, 4.8 vs. 6.8 cm3; P < 0.001) lower number antral follicles 7.5 11; 0.001). Further, they B leve...
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