Biological activity of artemisinin-naphthoquine phosphate on Schistosoma haematobium stages and the vector Bulinus truncatus

摘要: BACKGROUND Schistosoma haematobium infection is a major public health problem in most of Africa and the Middle East praziquantel remains only drug used for schistosomiasis control, therefore emergence resistance unavoidable. The antimalarial artemisinin-naphthoquine phosphate combination (co-ArNp) was recently documented to have promising effects on mansoni its snail host. METHODS We conducted this vitro study assess bioactivity co-ArNp S. vector Bulinus truncatus. RESULTS Treatment worms with 1 μg/ml 24 h reduced worm motility, while 20 resulted 25-100% mortality adult flukes within 48-72 h. Incubation miracidia cercariae molluscicidal (50% lethal concentration 7.5 μg/ml) killed all free larval stages 40 15 min, respectively. Also, exposure B. truncatus snails ppm combined regimen caused rate 100% CONCLUSIONS Co-ArNp therapy has also shown encouraging activity against other human schistosome, haematobium, as well vector.