Effects of paint thinner exposure on serum LH, FSH and testosterone levels and hypothalamic catecholamine contents in the male rat.

摘要: We have investigated the effects of thinner inhalation on serum LH, FSH and testosterone levels together with changes in hypothalamic catecholaminergic system male rat. A control group inhaled normal air ventilation. The remaining animals were divided into two groups exposed to paint a glassy cage for 15 or 30 d. Toluene concentration (the largest constituent thinner, 66%) was set at 3000 ppm air. At end, all decapitated blood samples obtained. Serum LH measured by RIA enzyme immunoassay. Following removal brains dry ice, medial preoptic area, suprachiasmatic nucleus, median eminence arcuate nucleus isolated micropunch technique. Noradrenaline, 3,4-dihydroxyphenylglycol (DHPG) dopamine concentrations these areas determined HPLC-ECD. Fifteen-day significantly suppressed parallel (p<0.001) compared values (LH: 0.77+/-0.07; testosterone: 2.67+/-0.39). Thirty-day exposure markedly decreased (p<0.001), but surprisingly had no significant effect testosterone. not altered either group. Thinner d did cause any change noradrenaline, DHPG regions examined (except nucleus). These results suggest that has an anti-gonadotropic may long-term endocrine disturbances male. It is thought involved inhibition secretion.