Taking a Toll on Self-Renewal: TLR-Mediated Innate Immune Signaling in Stem Cells.
作者： Alvaro G. Alvarado , Justin D. Lathia
DOI: 10.1016/J.TINS.2016.04.005
关键词:
摘要: Innate immunity has evolved as the front-line cellular defense mechanism to acutely sense and decisively respond microenvironmental alterations. The Toll-like receptor (TLR) family activates signaling pathways in response stimuli is well-characterized both resident infiltrating immune cells during neural inflammation, injury, degeneration. also been observed development disease, including stem progenitor that build brain are responsible for its homeostasis. Recently, activation of developmental programs malignant tumors emerged a driver growth via cancer cells. In this review we discuss how innate interfaces with cell maintenance normal neoplastic brain.
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