Corticosteroids and infliximab impair the performance of interferon-γ release assays used for diagnosis of latent tuberculosis
作者： Alexander Edwards , Yifang Gao , Raymond N Allan , Darran Ball , Hans de Graaf
DOI: 10.1136/THORAXJNL-2016-209397
关键词:
摘要: The impact of immunosuppression on interferon-γ release assays and novel cytokine biomarkers TB infection, mycobacteria-specific IL-2, IP-10 TNF-α responses was investigated in an ex vivo model. Cytokine standard QuantiFERON-TB Gold in-Tube (QFT-GIT) were compared with duplicate containing dexamethasone or infliximab. Dexamethasone converted QFT-GIT results from positive to negative 30% participants. Antigen-stimulated interferon-γ, IL-2 markedly reduced, but preserved. Infliximab caused result conversion up participants substantial reductions all responses. Therefore, corticosteroids anti-TNF-α agents significantly impair assay performance. may be a more robust biomarker than patients receiving corticosteroids.
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