Mycobacteria-Specific Cytokine Responses Detect Tuberculosis Infection and Distinguish Latent from Active Tuberculosis.
作者： Marc Tebruegge , Binita Dutta , Susan Donath , Nicole Ritz , Benjamin Forbes
DOI: 10.1164/RCCM.201501-0059OC
关键词:
摘要: Rationale: Current immunodiagnostic tests for tuberculosis (TB), including the tuberculin skin test and IFN-γ release assay (IGRA), have significant limitations, which include their inability to distinguish between latent TB infection (LTBI) active TB, a distinction critical clinical management.Objectives: To identify mycobacteria-specific cytokine biomarkers that characterize infection, determine diagnostic performance characteristics, establish whether these can LTBI TB.Methods: A total of 149 children investigated were recruited; all participants underwent QuantiFERON-TB Gold assay. In parallel, whole-blood assays using early secretory antigenic target-6, culture filtrate protein-10, PPD as stimulatory antigens undertaken, responses determined by xMAP multiplex assays.Measurements Main Results: IFN-γ, interferon-inducible protein-10 (IP-10), tumor necrosis factor (TN...
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