Survival and antigenic profile of irradiated malarial sporozoites in infected liver cells

摘要: Exoerythrocytic (EE) stages of Plasmodium berghei derived from irradiated sporozoites were cultured in vitro HepG2 cells. They synthesized several antigens, predominantly but not exclusively those expressed by normal early erythrocytic schizonts. After invasion, over half the intracellular sporozoites, both and irradiated, appeared to die. 24 h, marked contrast parasites, EE parasites continued break open, shedding their antigens into cytoplasm infected host Increasing radiation dosage, which has previously been shown reduce ability protect animals, correlated with reduced de novo antigen synthesis sporozoites.