Molecular analysis of the association of HLA-B53 and resistance to severe malaria.
作者： Adrian V. S. Hill , John Elvin , Anthony C. Willis , Michael Aidoo , Catherine E. M. Allsopp
DOI: 10.1038/360434A0
关键词:
摘要: The protective association between the human leukocyte antigen HLA-B53 and severe malaria was investigated by sequencing of peptides eluted from this molecule followed screening candidate epitopes pre-erythrocytic-stage antigens Plasmodium falciparum in biochemical cellular assays. Among malaria-immune Africans, HLA-B53-restricted cytotoxic T lymphocytes recognized a conserved nonamer peptide liver-stage-specific antigen-1 (LSA-1), but no were identified other antigens. These findings indicate possible molecular basis for HLA-disease support candidacy as vaccine component.
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