Epigenetic Codes Programing Class Switch Recombination.

摘要: Class switch recombination imparts B cells with a fitness-associated adaptive -advantage during humoral immune response by using precision-tailored DNA excision and ligation process to swap the default constant region gene of antibody new one that has unique effector functions. This secondary diversification repertoire is hallmark adaptability when confronted environmental pathogenic challenges. Given nucleotide sequence genes class switching remains unchanged (genetic constraints), it logical necessary therefore, integrate an epigenetic state, which dynamic can be heritably modulated before, after, or even antibody-dependent response. Epigenetic regulation encompasses heritable changes affect function (phenotype) without altering information embedded in gene, include histone, RNA modifications. Here, we review current literature on how use code language as means ensure plasticity light insults.