Charting the dynamic epigenome during B-cell development

摘要: The epigenetic landscape undergoes a widespread modulation during embryonic development and cell differentiation. Within the hematopoietic system, B cells are perhaps lineage with more dynamic DNA methylome their maturation process, which involves approximately one third of all CpG sites genome. Although each B-cell step displays its own methylation fingerprint, is extensively modified in particular transitions. These changes gradually accumulated specific chromatin environments as differentiation progresses reflect different features functional states cells. Promoters enhancers transcription factors acquire activation-related marks sequentially expressed windows. further reconfigure activity state target to regulate expression genes related functions. Together this observation, extensive areas outside gene regulatory elements such hypomethylation heterochromatic regions hypermethylation CpG-rich regions, also take place mature cells, intriguingly have been described hallmarks cancer. This process starts germinal center highly proliferative type, becomes particularly apparent long-lived memory plasma Overall, characterization not only provides insights into complex network that mediate but suggests late passively accumulate proliferation longevity.