Somatic Rearrangement in B Cells: It’s (Mostly) Nuclear Physics

作者: Erez Lieberman Aiden , Rafael Casellas

DOI: 10.1016/J.CELL.2015.07.034

关键词:

摘要: We discuss how principles of nuclear architecture drive typical gene rearrangements in B lymphocytes, whereas translocation hot spots and recurrent lesions reflect the extent AID-mediated DNA damage selection.

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