Association of the INS VNTR with size at birth

摘要: Size at birth is an important determinant of perinatal survival1 and has also been associated with the risk for cardiovascular disease type 2 diabetes in adult life2. Common genetic variation that regulates fetal growth could therefore influence survival predispose to development disease. We have tested insulin gene (INS) variable number tandem repeats (VNTR) locus, which Caucasians two main allele sizes (class I class III; ref. 3)r as a functional candidate polymorphism association size birth, it shown transcription INS (refs 3–5). In cohort 758 term singletons (Avon Longitudinal Study Pregnancy Childhood; ALSPAC6) followed longitudinally from years, we detected significant associations birth: III homozygotes had larger mean head circumference (P= 0.004) than homozygotes. These were amplified babies who did not show postnatal realignment (45%), evident length (P=0.015) weight (P=0.009) birth. The VNTR Ill/Ill genotype might bestowed during human history7 by conferring this kind may contribute reported between