Analysing early liver dysfunction after bone marrow transplantation

作者: Jan Storek , Robert Peter Gale , Leonard Goldstein

DOI: 10.1016/0966-3274(93)90043-8

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摘要: Liver dysfunction is a frequent early complication of bone marrow transplants, occuring in over 80% recipients HLA-identical transplants.1,2 Findings range from abnormal liver biochemical tests to coagulation abnormalities, ascites and hepatorenal failure. The most common causes (<100 daya) post-transplant are acute graft-versus-host disease (GvHD), intrahepatic veno-occlusive (VOD), drug-induced abnormalities infections.3–5 We discuss aetiology, pathogenesis, diagnosis, treatment prevention these disorders.

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