Separation of the enantiomers of coumarinic anticoagulant drugs by capillary electrophoresis using maltodextrins as chiral modifiers

摘要: The separation and quantitation of coumarinic anticoagulant drug enantiomers were achieved by direct chiral capillary electrophoresis using complex maltooligosaccharide mixtures as stereoselective electrolyte modifiers. Chiral separations characterized a high selectivity efficiency, enabling enantiomeric excess determinations. In addition, preliminary results indicate the applicability method for determination individual in biological samples. So can be used to perform pharmacokinetic studies. © 1994 Wiley-Liss, Inc.