Enantioselective Synthesis of Dilignol Model Compounds and Their Stereodiscrimination Study with a Dye-Decolorizing Peroxidase

摘要: A four-step enantioselective approach was developed to synthesize anti (1R,2S)-1a and (1S,2R)-1b containing a β-O-4 linkage in good yields. significant difference observed for the apparent binding affinities of four stereospecific lignin model compounds with TcDyP by surface plasmon resonance, which not translated into enzyme activities. The discrepancy may be attributed conformational change involving loop widely present DyPs upon H2O2 binding.