Galectin-9 Is Critical for Mucosal Adaptive Immunity through the T Helper 17-IgA Axis.

作者: Chih-Chia Liang , Chi-Shan Li , I-Chun Weng , Huan-Yuan Chen , Hsueh-Han Lu

DOI: 10.1016/J.AJPATH.2018.01.017

关键词:

摘要: … GT) expression was used to examine ongoing IgA class switching in LPS-stimulated B cells. … −/− B cells paradoxically underwent IgA class switching to a greater extent than Lgals9 +/+ B …

参考文章(49)
Derrick R. Samuelson, David A. Welsh, Judd E. Shellito, Regulation of lung immunity and host defense by the intestinal microbiota Frontiers in Microbiology. ,vol. 6, pp. 1085- 1085 ,(2015) , 10.3389/FMICB.2015.01085
Peter Bergqvist, Eva Gärdby, Anneli Stensson, Mats Bemark, Nils Y. Lycke, Gut IgA class switch recombination in the absence of CD40 does not occur in the lamina propria and is independent of germinal centers. Journal of Immunology. ,vol. 177, pp. 7772- 7783 ,(2006) , 10.4049/JIMMUNOL.177.11.7772
Guangxun Meng, Fuping Zhang, Ivan Fuss, Atsushi Kitani, Warren Strober, A Mutation in the Nlrp3 Gene Causing Inflammasome Hyperactivation Potentiates Th17 Cell-Dominant Immune Responses Immunity. ,vol. 30, pp. 860- 874 ,(2009) , 10.1016/J.IMMUNI.2009.04.012
S. K. Datta, M. Sabet, K. P. L. Nguyen, P. A. Valdez, J. M. Gonzalez-Navajas, S. Islam, I. Mihajlov, J. Fierer, P. A. Insel, N. J. Webster, D. G. Guiney, E. Raz, Mucosal adjuvant activity of cholera toxin requires Th17 cells and protects against inhalation anthrax. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 107, pp. 10638- 10643 ,(2010) , 10.1073/PNAS.1002348107
Jun Kunisawa, Masashi Gohda, Eri Hashimoto, Izumi Ishikawa, Morio Higuchi, Yuji Suzuki, Yoshiyuki Goto, Casandra Panea, Ivaylo I. Ivanov, Risa Sumiya, Lamichhane Aayam, Taichi Wake, So Tajiri, Yosuke Kurashima, Shiori Shikata, Shizuo Akira, Kiyoshi Takeda, Hiroshi Kiyono, Microbe-dependent CD11b + IgA + plasma cells mediate robust early-phase intestinal IgA responses in mice Nature Communications. ,vol. 4, pp. 1772- 1772 ,(2013) , 10.1038/NCOMMS2718
Masako Seki, Souichi Oomizu, Ken-mei Sakata, Atsuko Sakata, Tomohiro Arikawa, Kota Watanabe, Kanako Ito, Keisuke Takeshita, Toshiro Niki, Naoki Saita, Nozomu Nishi, Akira Yamauchi, Shigeki Katoh, Akihiro Matsukawa, Vijay Kuchroo, Mitsuomi Hirashima, Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis Clinical Immunology. ,vol. 127, pp. 78- 88 ,(2008) , 10.1016/J.CLIM.2008.01.006
N J Mantis, N Rol, B Corthésy, Secretory IgA's Complex Roles in Immunity and Mucosal Homeostasis in the Gut Mucosal Immunology. ,vol. 4, pp. 603- 611 ,(2011) , 10.1038/MI.2011.41
Keiji Hirota, Jan-Eric Turner, Matteo Villa, João H Duarte, Jocelyne Demengeot, Oliver M Steinmetz, Brigitta Stockinger, Plasticity of Th17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses. Nature Immunology. ,vol. 14, pp. 372- 379 ,(2013) , 10.1038/NI.2552
Youjin Lee, Amit Awasthi, Nir Yosef, Francisco J Quintana, Sheng Xiao, Anneli Peters, Chuan Wu, Markus Kleinewietfeld, Sharon Kunder, David A Hafler, Raymond A Sobel, Aviv Regev, Vijay K Kuchroo, None, Induction and molecular signature of pathogenic TH17 cells Nature Immunology. ,vol. 13, pp. 991- 999 ,(2012) , 10.1038/NI.2416