Viral infection and innate pattern recognition receptors in induction of Hashimoto's thyroiditis.

摘要: Hashimoto's thyroiditis, a common organ-specific autoimmune disease, is multifactorial in which both genetic susceptibility and environmental factors including infection play critical role its pathogenesis. Viral activates the innate adaptive immunity implicated as trigger of thyroiditis. Candidate viruses include hepatitis C virus human parvovirus B19. components, are recognized by receptors Toll-like (TLRs), detected thyroid tissues sera patients with While conflicting results have been obtained regarding TLRs diseases, our preliminary study suggested contribution TLR2 dectin-1 combination, TLR4, or TLR7 to production anti-thyroglobulin antibody nonobese diabetic mice, mouse model Despite interesting circumstantial evidence, however, whether viral involved development thyroiditis remains largely unclear. In this review, we summarize knowledge etiology