How Far Are We from Understanding the Genetic Basis of Hashimoto's Thyroiditis?
作者： Agata Jabrocka-Hybel , Anna Skalniak , Jakub Piątkowski , Dorota Pach , Alicja Hubalewska-Dydejczyk
DOI: 10.3109/08830185.2012.755175
关键词:
摘要: Hashimoto's thyroiditis (HT), an autoimmune thyroid disease (AITD), is becoming more and prevalent in the recent years. Data on family twin studies carry evidence for strong genetic influence AITD susceptibility development. The most common approaches to unravel background of those diseases are whole genome screening candidate gene analysis. Common Graves' (GD) genes have been identified, as well that characteristic only one diseases. Because complex nature AITD, caused by their polygenic a mode inheritance, there still questions be answered than answers can given, especially about thyroiditis. There plenty papers concerning pathogenesis AITD. However, not seldom do they end up conclusions GD, because results this far clearer unambiguous obtained HT. Similarly, meta-analyses reviews often concentrate general or GD alone. In review, main player. It aims review state art development disease.
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Michelle M.A. Fernando, Tim J. Vyse, Major Histocompatibility Complex Class II Systemic Lupus Erythematosus (Fifth Edition). pp. 3- 19 ,(2011) , 10.1016/B978-0-12-374994-9.10001-4
Brigitte Muller-Hilke, N. Avrion Mitchison, The role of HLA promoters in autoimmunity. Current Pharmaceutical Design. ,vol. 12, pp. 3743- 3752 ,(2006) , 10.2174/138161206778559759
Kazuki Morohoshi, Kouki Mori, Yurie Takahashi, Viral infection and innate pattern recognition receptors in induction of Hashimoto's thyroiditis. Discovery Medicine. ,vol. 12, pp. 505- 511 ,(2011)
R. Hall, J. B. Stanbury, Familial studies of autoimmune thyroiditis. Clinical and Experimental Immunology. ,vol. 2, pp. 719- ,(1967)
Caroline C. Whitacre, Sex differences in autoimmune disease Nature Immunology. ,vol. 2, pp. 777- 780 ,(2001) , 10.1038/NI0901-777
Hironori Ueda, Joanna MM Howson, Laura Esposito, Joanne Heward, Snook, Giselle Chamberlain, Daniel B Rainbow, Kara MD Hunter, Annabel N Smith, Gianfranco Di Genova, Mathias H Herr, Ingrid Dahlman, Felicity Payne, Deborah Smyth, Christopher Lowe, Rebecca CJ Twells, Sarah Howlett, Barry Healy, Sarah Nutland, Helen E Rance, Vin Everett, Luc J Smink, Alex C Lam, Heather J Cordell, Neil M Walker, Cristina Bordin, John Hulme, Costantino Motzo, Francesco Cucca, J Fred Hess, Michael L Metzker, Jane Rogers, Simon Gregory, Amit Allahabadia, Ratnasingam Nithiyananthan, Eva Tuomilehto-Wolf, Jaakko Tuomilehto, Polly Bingley, Kathleen M Gillespie, Dag E Undlien, Kjersti S Rønningen, Cristian Guja, Constantin Ionescu-Tîrgovişte, David A Savage, A Peter Maxwell, Dennis J Carson, Chris C Patterson, Jayne A Franklyn, David G Clayton, Laurence B Peterson, Linda S Wicker, John A Todd, Stephen CL Gough, None, Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease Nature. ,vol. 423, pp. 506- 511 ,(2003) , 10.1038/NATURE01621
K. Zaletel, B. Krhin, S. Gaberšček, A. Biček, T. Pajič, S. Hojker, Association of CT60 cytotoxic T lymphocyte antigen‐4 gene polymorphism with thyroid autoantibody production in patients with Hashimoto's and postpartum thyroiditis Clinical and Experimental Immunology. ,vol. 161, pp. 41- 47 ,(2010) , 10.1111/J.1365-2249.2010.04113.X
Dimitry A Chistiakov, Immunogenetics of Hashimoto's thyroiditis. Journal of Autoimmune Diseases. ,vol. 2, pp. 1- 21 ,(2005) , 10.1186/1740-2557-2-1
Julie Zikherman, Michelle Hermiston, David Steiner, Kiminori Hasegawa, Andrew Chan, Arthur Weiss, PTPN22 Deficiency Cooperates with the CD45 E613R Allele to Break Tolerance on a Non-Autoimmune Background Journal of Immunology. ,vol. 182, pp. 4093- 4106 ,(2009) , 10.4049/JIMMUNOL.0803317
Deirdre Cocks Eschler, Alia Hasham, Yaron Tomer, Cutting edge: the etiology of autoimmune thyroid diseases Clinical Reviews in Allergy & Immunology. ,vol. 41, pp. 190- 197 ,(2011) , 10.1007/S12016-010-8245-8