Major Histocompatibility Complex Class II

摘要: Publisher Summary Human leukocyte antigen (HLA) class I and II molecules are critical in mediating host defense responses through presentation immune tolerance by means of self/non-self recognition. Major histocompatibility complex (MHC) Class found only on antigen-presenting cells. The MHC has been significantly linked to systemic lupus erythematosus (SLE) one the 12 genome-wide linkage scans. most consistent HLA associations with SLE reside alleles. specificities, A1 B8, have SLE. However these alleles disease-associated B8-DR3 haplotype this effect likely results from LD. In past, strong LD observed at had made it difficult determine whether single or multiple independent loci were responsible for lupus. It is now clear that latter true unraveling interactions will provide next challenge dissecting contribution susceptibility. possibility major genetic influence may arise III region not classical requires confirmation. A meta-analysis high-density SNP studies currently underway as transethnic subphenotype analyses. should also help inform further research efforts refining association signals