Regulated secretion in vascular endothelium.

摘要: Eukaryotic cells secrete proteins through both regulated and constitutive pathways (1). In the pathway, exocytosis of stored material is coupled to an external stimulus which produces transient elevations in [Ca2+]i, cAMP or other secondary messengers (2, 3). Secretion ultimately accomplished by translocation exocytotic granule subcortical regions cell fusion cellular plasma membrane with membranes secretory organelle. The process secretion has at least two distinct consequences. First, rapid release contents storage generates locally high concentrations peptides, bioactive compounds vicinity cell. These products may promote cell-cell interaction activation target crosslinking surface receptors. Second, provide new additional binding sites for adhesion.