Histologic characteristics of skin cancer in Hiroshima and Nagasaki: Background incidence and radiation effects

摘要: Skin cancers, though rare in Japan, have reportedly been on the rise, but little else is known about epidemiologic features of different histologic types skin cancer. The Life Span Study cohort, which consists 93,700 atomic-bomb survivors, many whom were exposed to negligibly low radiation doses, and 26,600 people not radiation, enables a population-based study spontaneous as well radiation-related cancer risk. tumor incident cases diagnosed between 1958 1987 ascertained by linkage Hiroshima Nagasaki registries augmented searches other data sources. pathologists reviewed specimens pathology reports classified tumors using World Health Organization classification scheme. They identified 274 primary 106 basal cell carcinoma (BCC), 81 squamous (SCC), 14 malignant melanomas. Background incidence rates effects assessed Poisson regression models allowing for demographic covariates. BCC SCC background both 3 per 100,000 year. BCCs mainly head/neck (81%), whereas SCCs occurred most frequently arms/legs (45%) (29%), consistent with presumed role played solar UV exposure increased significantly 1987, remained unchanged. excess absolute risk unit surface area related did differ UV-exposed shielded parts body, suggesting additivity risks.