Tumor angiogenesis as a prognostic predictor in pancreatic cancer

摘要: The purpose of this study was to evaluate the role angiogenesis, proliferative activity (assessed by Ki-67 expression), p53 and ras-oncogene (H-ras) expression, conventional clinicopathologic factors in predicting overall survival rates patients with pancreatic ductal adenocarcinoma. We followed-up 22 adenocarcinoma pancreas for a median 19 months (range, 2 44 months). Angiogenesis quantitated as vascular surface density (VSD) number vessels per mm2 stroma (NVES) after microvessels were immunostained, using factor VIII-related antigen. p53, H-ras, proteins also determined immunohistochemically. VSD NVES showed significant correlations increased activity, poor tumor differentiation, size 3 cm or more (P = 0.001, P 0.013, 0.047, respectively). 2-year rate 33.3% high values significantly worse than that 66.6% estimated low microvessel count (log rank, 3.97; 0.046). In multivariate analysis Cox model, found be an independent prognostic 0.039). H-ras expressions not correlated angiogenesis parameters. conclude that, adenocarcinoma, is closely related growth patient survival.