Expression of transforming growth factor-beta-1 and p27Kip1 in pancreatic adenocarcinomas: relation with cell-cycle-associated proteins and clinicopathologic characteristics
作者： Nil Culhaci , Ozgul Sagol , Sedat Karademir , Huseyin Astarcioglu , Ibrahim Astarcioglu
关键词:
摘要: Background The purpose of our study was to investigate the immunohistochemical expression TGF-β1 and p27 in pancreatic adenocarcinomas compare findings with clinicopathological features survival. We also aimed evaluate context other cell cycle proliferation markers such as cyclin D1 Ki-67.
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Harlan I. Firminger, Atlas of tumor pathology Armed Forces Institute of Pathology. ,(1968)
Zhao Lu, Helmut Friess, Hans U. Graber, Xiaozhong Guo, Martin Schilling, Arthur Zimmermann, Murray Korc, Markus W. Buchler, Presence of two signaling TGF-β receptors in human pancreatic cancer correlates with advanced tumor stage Digestive Diseases and Sciences. ,vol. 42, pp. 2054- 2063 ,(1997) , 10.1023/A:1018814416903
Enrico Solcia, Carlo Capella, Günter Klöppel, Tumors of the Pancreas ,(1997)
Douglas B. Evans, Weixin Wang, Paul J. Chiao, Ana M. Grau, James L. Abbruzzese, Sanbao Ruan, Wei Zhang, Ling Zhang, Induction of p21waf1 expression and growth inhibition by transforming growth factor beta involve the tumor suppressor gene DPC4 in human pancreatic adenocarcinoma cells. Cancer Research. ,vol. 57, pp. 3929- 3934 ,(1997)
Antonio L. Cubilla, Patrick J. Fitzgerald, Tumors of the Exocrine Pancreas ,(1984)
R. Govinden, K.D. Bhoola, Genealogy, expression, and cellular function of transforming growth factor-β Pharmacology & Therapeutics. ,vol. 98, pp. 257- 265 ,(2003) , 10.1016/S0163-7258(03)00035-4
Tracey A. Holland, Jackie Elder, Jonathan M. McCloud, Christine Hall, Mark Deakin, Anthony A. Fryer, James B. Elder, Paul R. Hoban, Subcellular localisation of cyclin D1 protein in colorectal tumours is associated with p21WAF1/CIP1 expression and correlates with patient survival International Journal of Cancer. ,vol. 95, pp. 302- 306 ,(2001) , 10.1002/1097-0215(20010920)95:5<302::AID-IJC1052>3.0.CO;2-#
R. J. Michalides, Cell cycle regulators: mechanisms and their role in aetiology, prognosis, and treatment of cancer. Journal of Clinical Pathology. ,vol. 52, pp. 555- 568 ,(1999) , 10.1136/JCP.52.8.555
Dawn Sears, Richard A. Erickson, Lubna Sayage-Rabie, Martha C. Escobar, TGF- β and p53 Staining in CT-Guided and Endoscopic Ultrasound Fine-Needle Aspirates of Pancreatic Adenocarcinoma Digestive Diseases and Sciences. ,vol. 49, pp. 828- 832 ,(2004) , 10.1023/B:DDAS.0000030095.71501.04
Cai-De Lu, Shinsho Morita, Takashi Ishibashi, Hitoshi Hara, Hiroshi Isozaki, Nobuhiko Tanigawa, Loss of p27Kip1 expression independently predicts poor prognosis for patients with resectable pancreatic adenocarcinoma. Cancer. ,vol. 85, pp. 1250- 1260 ,(1999) , 10.1002/(SICI)1097-0142(19990315)85:6<1250::AID-CNCR6>3.0.CO;2-#