Role of the membrane skeleton in creation of microdomains.

摘要: The membrane skeleton is a specialized part of the cytoskeleton that in close proximity to cell with protein composition and structure differs from bulk cytoskeleton. various transmembrane proteins bound it form mosaic compartments responsible for temporary confinement lipids controls rate their repetitive hop movements between these skeleton-based compartments, known as “hop diffusion”, found by observation single-molecule diffusion. Such diffusion has been be universal compartment sizes range 30 700 nm, depending on type. directly involved temporal molecules successfully imaged raster scanning single molecule using an optical trap (single force imaging). compartmentalization enables dynamic spatial regulation signal transduction plasma membrane, arresting signaling complexes activated receptor enlarged, stabilized rafts within compartment. Furthermore, high concentrations its associated immobile are formation polarity such across initial segment axon body neurons. Argument advanced creation domains must influenced skeleton.