Serotonergic-catecholaminergic interactions and foot shock-induced jumping behavior in rats

摘要: Abstract The role of serotonergic neurons in foot shock-induced jumping behavior was evaluated by studying the effects serotonin agonists and depletors under conditions increasing activity catecholaminergic combining different shock intensities with methamphetamine or clonidine pretreatment. Low (40 V) suppressed three kinds agonists: 5-hydroxytryptophan (50 100 mg/kg), 5-methoxydimethyltryptamine (1 5 mg/kg) clomipramine (5 but these drugs did not suppress high (60 jumping. A depletor brain serotonin, p-chlorophenylalanine (200 failed to affect induced both intensities. inhibitory effect on low abolished pretreatment (100 μg/kg). Furthermore, a postsynaptic receptor stimulant, potentiated rats pretreated (3 mg/kg). results indicated that activation has differential ranging from facilitatory, depending upon neurons.