The Role of Serotonin in Modulation of Nociceptive Reflexes

摘要: During the past fifteen years, a variety of evidence has accumulated which is consistent with Brodie and Shore (1957) hypothesis that serotonergic neurons in central nervous system serve tropotrophic role (Hess, 1954) inhibiting an animal’s response to diverse arousing stimuli (Harvey et al., 1975). This for serotonin is, perhaps, most thoroughly documented studies dealing painful stimuli. The results numerous suggest decreases activity result hyperalgesia while increases produce analgesia 1975; Mayer Price, 1976; Messing Lytle, 1977). Thus one can assume normally lead increased within partially inhibits or diminishes intensity nociceptive reflex. view determining resulted from application wide techniques altering function assessing pain sensitivity. Such convergent approach important, since no single technique be relied on alteration without also having additional effects, some are known others yet discovered. Similarly, not unitary phenomenon, there priori reason assuming should have equivalent inhibitory effect all reflexes. In fact, different reflexes involve portions system, it would more surprising if form selectivity did exist. Most investigators, including ourselves, sometimes ignored these caveats by placing too great reliance procedure As precise recently been obscured conflicting conclusions apparently contradictory data. Accordingly, this paper will review concerning nociception, special attention given means employed