Disappearance of supra-ependymal 5-HT axons in the rat forebrain after electrolytic and 5,6-DHT-induced lesions of the medial forebrain bundle
作者： H.P. Lorez , L. Pieri , J.G. Richards
DOI: 10.1016/0006-8993(75)90238-3
关键词:
摘要: Abstract The present study was intended to demonstrate the origin of supra-ependymal 5-hydroxytryptamine axons in rat forebrain. Electrolytic lesions and injections 5,6-dihydroxytryptamine (10 ωg 4 ωl) were carried out unilaterally close medial forebrain bundle posterior hypothalamus rats. Ten 14 days later, terminal formaldehyde-induced indolealkylamine fluorescence had virtually disappeared supra-ependymally lateral ventricles interventricular foramina ipsilateral lesion if passing through part been destroyed. No changes observed, electron microscopically or histochemically, contralateral lesion. It is concluded that serotonergic nerve terminals originate, uncrossed, from non-terminal hypothalamus.
elsevier.com
sci-hub.se 参考文章(24)
L. Pieri, H.P. Lorez, J.G. Richards, Tracing transmitter-specific neuronal systems in the mammalian brain: Supra-ependymal, serotonergic nerve fibres (T) British Journal of Pharmacology. ,vol. 52, ,(1974)
Anders BjÖRklund, Bengt Falck, Ulf Stenevi, Microspectrofluorimetric Characterization of Monoamines in the Central Nervous System: Evidence for a New Neuronal Monoamine-like Compound Progress in Brain Research. ,vol. 34, pp. 63- 73 ,(1971) , 10.1016/S0079-6123(08)63954-0
K FUXE, T HOKFELT, U UNGERSTEDT, Localization of indolealkylamines in CNS. Advances in pharmacology. ,vol. 6, pp. 235- 251 ,(1968) , 10.1016/S1054-3589(08)61177-1
Fuxe K, Dahlstroem A, EVIDENCE FOR THE EXISTENCE OF MONOAMINE-CONTAINING NEURONS IN THE CENTRAL NERVOUS SYSTEM. I. DEMONSTRATION OF MONOAMINES IN THE CELL BODIES OF BRAIN STEM NEURONS. Acta Physiologica Scandinavica. ,vol. 62, pp. 1- 55 ,(1964)
Joachim F. R. König, Renate A. Klippel, The rat brain: A stereotaxic atlas of the forebrain and lower parts of the brain stem ,(1986)
Alfred Heller, John A. Harvey, Robert Y. Moore, A demonstration of a fall in brain serotonin following central nervous system lesions in the rat Biochemical Pharmacology. ,vol. 11, pp. 859- 860 ,(1962) , 10.1016/0006-2952(62)90181-8
Irwin J. Kopin, Palkovits Miklos, Ronald M. Kobayashi, David M. Jacobowitz, Quantitative relationship of catecholamine content and histofluorescence in brain of rats Brain Research. ,vol. 80, pp. 229- 235 ,(1974) , 10.1016/0006-8993(74)90687-8
J. G. Richards, J. P. Tranzer, Ultrastructural evidence for the localization of an indolealkylamine in supra-ependymal nerves from combined cytochemistry and pharmacology Experientia. ,vol. 30, pp. 287- 289 ,(1974) , 10.1007/BF01934832
A. Björklund, B. Falck, U. Stenevi, Classification of monoamine neurones in the rat mesencephalon: Distribution of a new monoamine neurone system Brain Research. ,vol. 32, pp. 269- 285 ,(1971) , 10.1016/0006-8993(71)90324-6
A. Bj�rklund, A. Nobin, U. Stenevi, The use of neurotoxic dihydroxytryptamines as tools for morphological studies and localized lesioning of central indolamine neurons Cell and Tissue Research. ,vol. 145, pp. 479- 501 ,(1973) , 10.1007/BF00306720