Simultaneous quantification of vinblastine and desacetylvinblastine concentrations in canine plasma and urine samples using LC-APCI-MS/MS.
作者： Satyanarayana Achanta , Minh Ngo , Allison Veitenheimer , Lara K. Maxwell , Jarrad R. Wagner
DOI: 10.1016/J.JCHROMB.2012.11.012
关键词:
摘要: A highly sensitive and specific liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry (LC/APCI-MS/MS) method has been developed validated for simultaneous quantification of vinblastine its metabolite, desacetylvinblastine, in canine plasma urine samples. Plasma samples were processed by a solid phase extraction procedure. The optimal chromatographic behavior these analytes was achieved on pentafluorophenyl (PFP) propyl analytical column (5μm, 50×2.1mm) under isocratic elution 0.75mL/min with mobile 5mM ammonium acetate methanol. analyzed positive ion, multiple reaction monitoring mode. calibration curves linear over 0.125-2ng/mL (lower curve); 2-100ng/mL (higher curve) 0.125-5ng/mL desacetylvinblastine plasma, 1-2000ng/mL 0.5-100ng/mL samples, respectively. limits quantitation 0.125ng/mL both matrices. intra interday accuracy above 89% precision below 8.6% successfully applied to ongoing vivo pharmacokinetic studies dogs.
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