Low-Energy Shockwave Therapy Improves Ischemic Kidney Microcirculation.

摘要: Microvascular rarefaction distal to renal artery stenosis is linked dysfunction and poor outcomes. Low-energy shockwave therapy stimulates angiogenesis, but the effect on kidney microvasculature unknown. We hypothesized that low-energy would restore microcirculation alleviate in renovascular disease. Normal pigs subjected 3 weeks of were treated with six sessions (biweekly for consecutive weeks) or left untreated. assessed BP, urinary protein, stenotic blood flow, GFR, microvascular structure, oxygenation vivo 4 after completion treatment, then, we expression angiogenic factors mechanotransducers (focal adhesion kinase β1-integrin) ex A 3-week regimen attenuated hypertension, normalized density oxygenation, stabilized function, alleviated fibrosis stenosis. These effects associated elevated mechanotransducers, particularly proximal tubular cells. In additional prolonged (6 stenosis, also decreased BP improved density, kidney. This did not cause detectable injury normal pigs. conclusion, improves likely part by mechanotransduction-mediated cells, it may ameliorate hypertension. serve as a novel noninvasive intervention management