Low-Energy Extracorporeal Shock Wave Ameliorates Streptozotocin Induced Diabetes and Promotes Pancreatic Beta Cells Regeneration in a Rat Model.

摘要: Traditional therapy for diabetes mellitus has focused on supportive treatment, and is not significant in the promotion of pancreatic beta cells regeneration. We investigated effect low- energy extracorporeal shock wave (SW) a streptozotocin induced (DM) rat model. Methods: The DM rats were treated with ten sessions low-energy SW (weekly consecutive weeks) or left untreated. assessed blood glucose, hemoglobin A1c (HbA1c), urine volume, islets area, c-peptide, glucagon-like peptide 1 (GLP-1) insulin production, number, tissue inflammation, oxidative stress, apoptosis, angiogenesis, stromal cell derived factor (SDF-1) weeks after completion treatment. Results: ten- week regimen significantly reduced HbA1c, volume as well enhancing GLP-1, production model DM. Moreover, increased number rats. This was likely primarily attributed to fact that stress increasing proliferation, repair potency. Conclusions: Low-energy preserved function streptozotocin-induced may serve novel noninvasive effective treatment