The derivatives of the Wnt3a lineage in the central nervous system.

摘要: The dorsal midline of the vertebrate neural tube is a source signals that direct cell fate specification and proliferation. Using genetic mapping in mouse previously generated Wnt3aCre line, we report here genetically labeled cells Wnt3a lineage migrate widely from into half adult brain spinal cord, contributing to diverse structures diencephalon, midbrain, brainstem extensively populating rostral cord. Conspicuously, many these are linked specific functional networks. populate nuclei central auditory system medulla thalamus, trigeminal sensory cervical cord midbrain. Our findings reveal rich contributions variety show functionally integrated can share molecular identity, provided by transient gene expression early their development.