Unilateral and bilateral pallidotomy for idiopathic Parkinson's disease: A case series of 115 patients

摘要: Lesioning of the internal pallidum is known to improve symptoms idiopathic Parkinson's disease (PD) and alleviate dyskinesia motor fluctuations related levodopa therapy. The benefit obtained contralateral a single lesion insufficient in some cases when are bilaterally disabling. However, reports unacceptably high rates adverse effects after bilateral pallidotomy have limited its use such cases. We report on outcome unilateral (UPVP) (BPVP) posteroventral consecutive case series 115 patients with PD United Kingdom Australia. After 3 months, UPVP resulted 27% reduction off medication Part III (motor) Unified Disease Rating Scale score abolition 40% For BPVP, these figures were increased 31% 63%, respectively. Follow-up smaller group 12 months found scores be worsening but activities daily living was maintained. Speech adversely affected although change small most Unilateral can performed safely without microelectrode localisation. Bilateral appears more effective, particularly reducing dyskinesia; our experience, side not been as reported by other groups.