Antinociceptive roles of galanin receptor 1 in nucleus accumbens of rats in a model of neuropathic pain
作者： Hao Duan , Ying Zhang , Xiao-Min Zhang , Huan-Huan Xu , Jun Shu
DOI: 10.1002/JNR.23611
关键词:
摘要: It has been reported that galanin and its receptors might be involved in the modulation transmission of nociception central nervous system. Our previous research also demonstrated induces antinociception nucleus accumbens (NAc) intact rats. However, interaction between NAc underlying mechanism suppressing pain remain unclear. The present study seeks to determine induced by receptor (GalR)-1 stimulation rats with neuropathic pain. left sciatic nerve was ligated mimic a model. Western blots showed expression GalR1 significantly upregulated Intra-NAc injection agonist M617 dose-dependent increase hindpaw withdrawal latency (HWL) noxious thermal mechanical stimulations Also, effect attenuated M35, GalR1/2 antagonist; at same time, M35 reduced galanin-induced antinociception, suggesting mediates Furthermore, we found M617-induced stronger than We injections each significant increases HWL, but M617. All these results suggest plays an important role other GalRs are
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