Spexin-expressing neurons in the magnocellular nuclei of the human hypothalamus

摘要: Neuropeptides are involved in numerous brain activities being responsible for a wide spectrum of higher mental functions. The purpose this concise, structural and qualitative investigation was to map the possible immunoreactivity novel neuropeptide spexin (SPX) within human magnocellular hypothalamus. SPX is newly identified peptide, natural ligand galanin receptors (GALR) 2/3, with no molecular structure similarities currently known regulatory factors. seems have multiple physiological functions, an involvement reproduction food-intake regulation recently revealed animal studies. For first time we describe expressing neurons supraoptic (SON) paraventricular (PVN) nuclei hypothalamus using immunohistochemical fluorescent methods, key regions mechanisms osmotic homeostasis, energy expenditure, consummatory behaviour, reproductive processes, social recognition stress responses. vast majority located both examined neurosecretory show abundant expression may indirectly implicate potential contribution signalling hypothalamic physiology brain.