Epigenetic mechanisms in cartilage and osteoarthritis: DNA methylation, histone modifications and microRNAs.
作者： M.J. Barter , C. Bui , D.A. Young
DOI: 10.1016/J.JOCA.2011.12.012
关键词:
摘要: Osteoarthritis (OA) is a complex multifactorial disease with strong genetic component. Several studies have suggested or identified epigenetic events that may play role in OA progression and the gene expression changes observed diseased cartilage. The aim of this review to inform about current research epigenetics OA. Epigenetic mechanisms include DNA methylation, histone modifications, microRNAs. Collectively, these enable cell respond quickly environmental can be inherited during division. However, aberrant modifications are associated number pathological conditions, including Advancements suggests global analysis such now possible, however, exception microRNAs, it will significant challenge demonstrate how impact on disease.
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