MRI phenotype of breast cancer: Kinetic assessment for molecular subtypes.
作者： Eric Blaschke , Hiroyuki Abe
DOI: 10.1002/JMRI.24884
关键词:
摘要: Purpose To evaluate the dynamic contrast-enhanced magnetic resonance imaging (MRI) kinetic characteristics of newly diagnosed breast cancer molecular subtypes. Materials and Methods Breast MRI examinations 112 patients with were reviewed. Cases invasive ductal carcinoma sorted by subtype (28 TN, 11 HER2 +, 73 Lum A/B) field strength, lesion segmentation analyses performed on a dedicated workstation. For assessment, 50% 100% thresholds employed for display medium rapid uptake. Kinetic profiles in terms percent volume six types (medium-persistent, medium-plateau, medium-washout, fast-persistent, fast-plateau, fast-washout) relative to whole obtained. Statistical analysis was using Welch's t-test. Results Percent HER2-positive lesions >100% uptake at early phase 3T strength exams significantly greater compared luminal A/B (93.8 ± 0.92 vs. 77.3 ± 7.2; P HER2+ also higher than (99.1 ± 0.73 93.6 ± 3.05; trended without reaching significance. Conclusion The tumors demonstrating contrast is increased other subtypes. J. Magn. Reson. Imaging 2015;42:920–924.
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