Gene Expression during the Distinct Stages of Candidiasis

摘要: This chapter summarizes some of the known and proposed infection strategies underlying transcriptional responses which govern them. Although similar may be used by other pathogenic Candida species are commonly found as commensals, focus is on albicans most common best-investigated species. The ability C. to colonize surfaces therefore constitutes a vital first step in many forms candidiasis. In nature, gastrointestinal (GI) tracts neither rats nor mice colonized albicans, order establish colonization, form treatment such use antibiotics usually necessary. Certain predisposing conditions permit switch from harmless commensal oral mucosa an aggressive pathogen able cause superficial infections cavity oropharyngeal regions. commensally tissue could then monitored detect natural fluctuations gene expression cavity. Simultaneously, transcript profile disease state determined over time. To study virulence properties mouse model, two routes used. Intravenous results direct hematogenous dissemination via bloodstream. Another method for inducing invasive candidiasis intraperitoneal infection.