Factor V inhibitors: rare or not so uncommon? A multi-laboratory investigation.

摘要: Acquired deficiencies of, or inhibitors to, factor V are considered rare events. We report a series of 14 acquired deficiencies, 10 which were confirmed to have V, as identified within Australia in the past 5 years following multi-laboratory investigation. The initial index case seen by one laboratory was followed 4 months separate similar case. This prompted local contact with colleagues (n = 20) working other haemostasis referral laboratories identify current series. In total, nearly one-half all contacted had years. Clinical features and apparent associated risk bleeding complications generally varied, did findings likely causal event. There three females 11 males. Age ranged from 44 95 (median, 81 years). level inhibitor undetectable over 250 Bethesda units. probable cause leading development exposure bovine thrombin, antibiotics, surgery malignancy. Of additional interest association anti-phospholipid antibodies many cases. For example, two cases, titres > 200 units, high levels anti-cardiolipin (> 70 GPL units) also detected. Although less clear because interference, cases showed evident co-associated lupus anticoagulant activity. conclusion, we recently our geographic region that would represent an annual incidence around 0.29 per million Australians. finding, there is likelihood most will see every five so