IMMUNOBIOLOGY OF THE HUMAN TROPHOBLAST

摘要: This chapter discusses immunobiology of the human trophoblast. Trophoblast represents entire fetal cellular site continuous and direct contact extraembryonic tissue with maternal blood, within haemochorial placentation pregnancy. fascinating cell exhibits many characteristic biological functions that are particular to its special location as boundary tissue, include property invasiveness, transfer nutrients passive immunity from tissues, a major influence on endocrinological events in pregnancy, presumed essential role materno–fetal immunological interplay. Detailed immunohistological immunochemical studies, particularly using monoclonal antibodies reactive monomorphic determinants HLA structures, have established conceptus is surrounded placenta chorionic membrane throughout gestation by trophoblast failing express either class I (HLA-A, -B, -C) or Class II (HLADR) histocompatibility gene complex (MHC) antigens. Some cytotrophoblast membrane, usually toward side, appear MHC antigens—although commonly there HLA-negative layer at side chorion.