Elevated vitreous concentration of monoclonal immunoglobulin manifesting as schlieren in juvenile rheumatoid arthritis-associated uveitis.
作者： Richard L. Humphrey , Quan Dong Nguyen , Mark S. Humayun , James P. Dunn
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摘要: We report the clinical findings and analysis of immunoglobulin (Ig) composition vitreous a 10-year-old girl with juvenile rheumatoid arthritis–associated uveitis. The had schlieren appearance at time pars plana lensectomy vitrectomy. Analysis fluid revealed marked elevation IgG, IgM, IgA, albumin levels relative to fluids from control patients without coefficients were also elevated for IgG IgM classes immunoglobulins. Immunofixation electrophoresis 2 distinct bands restricted electrophoretic mobility. These studies suggest that there may be local (intraocular) production immunoglobulins as an immunologic response in ocular inflammatory diseases such uveitis this monoclonal (possibly biclonal or oligoclonal) nature.
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