Strategies for Dealing With the Immunogenicity of Therapeutic Proteins

摘要: As proteins and peptides (hereinafter referred to collectively as “proteins”) are major components of biological processes, it is logical assume that their potential for use therapeutics would be extremely high. However, the recognizable need a defense system has implications administration protein-based pharmaceuticals (Table 1). Minor differences in primary structure proteins—even little one amino acid from human form protein—have been shown sufficient immune recognition.