Induction in vivo of cartilage grafts for craniofacial reconstruction.

摘要: In the craniofacial region, defects of cartilage structures are preferably reconstructed with autologous cartilage. Donor-site morbidity related to creation a new defect elsewhere, and lack growth potential graft--mandatory in children--have stimulated investigators find other ways generate "extra" Several biomaterials have been tested as matrix for ingrowth (peri)chondroblasts experimental animals. young (growing) rabbits we developed process heterotopic induction use demineralized (bovine) bone which is enfolded pedicled flap ear perichondrium at least three weeks. During this period colonized by macrophages polymorphonuclear cells start complete biodegradation material. Simultaneously, collagen invaded mesenchymal cells, originating from differentiating into chondroblasts later, chondrocytes forming intercellular substance. The developing, very could be demonstrated type II, thus, hyaline When applied its adherent graft, it merges easily more matured host even appears capable further growth. Therefore, seems suitable reconstruction cartilaginous growing like nasal septum or larynx.