Chicago sky blue and a helium neon laser abolish endothelium dependent relaxation in vivo in the microcirculation.

摘要: Chicago sky blue, also known as Niagara is a vital dye that can successfully be used an intravascular energy absorbing target for the light from helium-neon (HeNe) laser. The result of this light/dye interaction endothelium damage which controlled by adjusting duration laser exposure and amount injected intravenously. endothelial probably heat generated dyes absorption at interface between plasma endothelium. most minimal resulted in selective loss dilation normally produced acetylcholine bradykinin, two dependent dilators. sodium nitroprusside, dilator acting directly on vascular smooth muscle, was preserved. More severe injury (i.e. more prolonged to and/or dye), local platelet aggregation site impact.