作者: Zhen Tian , Meng Wang , Aiying Zhang , Zengguo Feng
DOI: 10.1007/S11706-007-0029-6
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摘要: This paper describes a preliminary study on the synthesis of glycopeptide-based triblock copolymers and their aggregate behavior in water. Initially, polypeptide-based copolymer, poly(L-lysine)-b-poly(tetrahydrofuran)-b-poly(L-lysine) (PLL30-b-PTHF-b-PLL30), was synthesized by ring-opening polymerization ɛ-benzyloxycarbonyl-L-lysine N-carboxyanhydride using amine-terminated poly(tetrahydrofuran) as macroinitiator fixed feed ratio, followed removal protecting group. The resulting copolymer then reacted with varying amount D-gluconolactone presence dipropylethylamine to give corresponding high yields. kind amphiphilic sugar-containing can self-assemble into nano-sized aggregates critical aggregation concentration (CAC) determined range around 10−6 M fluorescence measurement. spherical morphologies 100–150 nm scale were also evidenced transmission electron microscopy (TEM) measurements. They show potential carriers for drug controlled delivery templates biomimetic mineralization.