Self-Emulsifying Drug Delivery Systems: Strategy for Improving Oral Delivery of Poorly Soluble Drugs
作者： Jing-ling Tang , Jin Sun , Zhong-Gui He
DOI: 10.2174/157488507779422400
关键词:
摘要: Drugs are most often administered by the oral route. However, more than 40% of new chemical entities exhibit poor aqueous solubility, resulting in unsatisfactory oral drug delivery. …
eurekaselect.com参考文章(68)
Nissen Nn, Sehested M, Demant Ej, Jensen Pb, Friche E, The solvents cremophor EL and Tween 80 modulate daunorubicin resistance in the multidrug resistant Ehrlich ascites tumor. Cancer communications. ,vol. 2, pp. 297- 303 ,(1990)
Susan A. Charman, William N. Charman, Mark C. Rogge, Terry D. Wilson, Frank J. Dutko, Colin W. Pouton, Self-emulsifying drug delivery systems: formulation and biopharmaceutic evaluation of an investigational lipophilic compound. Pharmaceutical Research. ,vol. 9, pp. 87- 93 ,(1992) , 10.1023/A:1018987928936
Jay M. Dintaman, Jeffrey A. Silverman, Inhibition of P-Glycoprotein by D-α-Tocopheryl Polyethylene Glycol 1000 Succinate (TPGS) Pharmaceutical Research. ,vol. 16, pp. 1550- 1556 ,(1999) , 10.1023/A:1015000503629
Elena V. Batrakova, Shu Li, Donald W. Miller, Alexander V. Kabanov, Pluronic P85 increases permeability of a broad spectrum of drugs in polarized BBMEC and Caco-2 cell monolayers Pharmaceutical Research. ,vol. 16, pp. 1366- 1372 ,(1999) , 10.1023/A:1018990706838
Elena Batrakova, Shengmin Lee, Shu Li, Annie Venne, Valery Alakhov, Alexander Kabanov, Fundamental Relationships Between the Composition of Pluronic Block Copolymers and Their Hypersensitization Effect in MDR Cancer Cells Pharmaceutical Research. ,vol. 16, pp. 1373- 1379 ,(1999) , 10.1023/A:1018942823676
Vijaya D. Makhey, Ailan Guo, Daniel A. Norris, Peidi Hu, Jiansheng Yan, Patrick J. Sinko, Characterization of the regional intestinal kinetics of drug efflux in rat and human intestine and in Caco-2 cells. Pharmaceutical Research. ,vol. 15, pp. 1160- 1167 ,(1998) , 10.1023/A:1011971303880
Panayiotis P. Constantinides, Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects Pharmaceutical Research. ,vol. 12, pp. 1561- 1572 ,(1995) , 10.1023/A:1016268311867
Manoj M. Nerurkar, Philip S. Burton, Ronald T. Borchardt, The use of surfactants to enhance the permeability of peptides through Caco-2 cells by inhibition of an apically polarized efflux system. Pharmaceutical Research. ,vol. 13, pp. 528- 534 ,(1996) , 10.1023/A:1016033702220
Tatyana Gershanik, Sharon Benzeno, Simon Benita, Interaction of a self-emulsifying lipid drug delivery system with the everted rat intestinal mucosa as a function of droplet size and surface charge. Pharmaceutical Research. ,vol. 15, pp. 863- 869 ,(1998) , 10.1023/A:1011968313933
Yongyut Rojanasakul, Li‐Ying Wang, Meenakshi Bhat, Douglas D. Glover, Carl J. Malanga, Joseph K. H. Ma, The transport barrier of epithelia: a comparative study on membrane permeability and charge selectivity in the rabbit. Pharmaceutical Research. ,vol. 9, pp. 1029- 1034 ,(1992) , 10.1023/A:1015802427428