Dynamic magnetic resonance imaging assessment of vascular targeting agent effects in rat intracerebral tumor models.

摘要: We used dynamic MRI to evaluate the effects of monoclonal antibodies targeting brain tumor vasculature. Female athymic rats with intracerebral human xenografts were untreated or treated intetumumab, α(V)-integrins, bevacizumab, vascular endothelial growth factor (n = 4-6 per group). Prior treatment and at 1, 3, 7 days after treatment, we performed standard assess volume, susceptibility-contrast blood-pool iron oxide nanoparticle ferumoxytol relative cerebral blood volume (rCBV), contrast-enhanced permeability. Tumor rCBV increased by 27 ± 13% over in rats; intetumumab 65 10%, whereas bevacizumab reduced 31 10% (P < .001 for group day). Similarly, permeability compared controls 3 decreased within 24 hours .0004 group, P .0081 All tumors grew 7-day assessment period, but slowed increase on MRI. conclude that agents had diametrically opposite vasculature rat models. Targeting α(V)-integrins both measures. These findings have implications chemotherapy delivery antitumor efficacy.